Table 3.
Mediation analysis between BMI/WC and blood pressure in the Harbin Cohort Study on Diet, Nutrition and Chronic Non-Communicable Diseases (HDNNCDS, 2012).
| Mediators (by 1 SD) | Outcomes | BMI* | WC* | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Total effect, estimate (95% CI) | Proportion via mediation, estimate (95% CI) | Sensitivity analysis | Total effect, estimate (95% CI) | Proportion via mediation, estimate (95% CI) | Sensitivity analysis | ||||
| R2* | R2* | ||||||||
| TG | SBP | 2.496 (2.013,2.890) | 0.090 (0.057,0.137) | 0.01 | 0.0073 | 3.254 (2.939,2.758) | 0.066 (0.040,0.090) | 0.01 | 0.0072 |
| DBP | 1.155 (0.879,1.350) | 0.134 (0.090,0.184) | 0.01 | 0.0081 | 1.345 (1.118,1.584) | 0.114 (0.087,0.155) | 0.01 | 0.0081 | |
| TC | SBP | 2.496 (2.142,2.904) | 0.018 (0.006,0.033) | 0.01 | 0.0077 | 3.254 (2.809,3.716) | 0.018 (0.009,0.034) | 0.01 | 0.0076 |
| DBP | 1.155 (0.918,1.346) | 0.021 (0.006,0.040) | 0.01 | 0.0086 | 1.345 (1.128,1.568) | 0.024 (0.009,0.039) | 0.01 | 0.0086 | |
| HDL | SBP | 2.494 (2.150,2.886) | −0.013 (−0.043,0.028) | NA | NA | 3.250 (2.899,3.767) | −0.013 (−0.042,0.019) | NA | NA |
| DBP | 1.153 (0.092,1.360) | 0.018 (−0.031,0.063) | NA | NA | 1.344 (1.137,1.479) | 0.016 (−0.023,0.058) | NA | NA | |
| LDL | SBP | 2.491 (1.965,2.864) | 0.014 (−0.001,0.032) | NA | NA | 3.251 (2.838,3.647) | 0.008 (−0.0003,0.020) | NA | NA |
| DBP | 1.149 (0.959,1.378) | 0.012 (−0.006,0.030) | NA | NA | 1.340 (1.135,1.553) | 0.008 (−0.004,0.023) | NA | NA | |
| FG | SBP | 2.491 (2.052,0.822) | 0.048 (0.031,0.070) | 0.01 | 0.0049 | 3.252 (2.856,3.638) | 0.043 (0.026,0.057) | 0.01 | 0.0048 |
| DBP | 1.154 (0.971,1.429) | 0.040 (0.021,0.065) | 0.01 | 0.0055 | 1.344 (1.124,1.568) | 0.040 (0.022,0.065) | 0.01 | 0.0055 | |
| PG | SBP | 2.561 (2.117,3.041) | 0.045 (0.019,0.079) | 0.01 | 0.0052 | 3.277 (2.866,3.815) | 0.034 (0.016,0.051) | 0.01 | 0.0051 |
| DBP | 1.218 (0.959,1.469) | 0.039 (0.017,0.066) | 0 | 0 | 1.435 (1.218,1.646) | 0.033 (0.011,0.064) | 0 | 0 | |
| FI | SBP | 2.642 (2.263,3.184) | 0.120 (0.048,0.181) | 0.01 | 0.0074 | 3.072 (2.058,3.670) | 0.102 (0.032,0.163) | 0.01 | 0.0073 |
| DBP | 1.114 (0.812,1.467) | 0.198 (0.125,0.316) | 0.01 | 0.0082 | 1.211 (0.917,1.495) | 0.197 (0.117,0.298) | 0.01 | 0.0082 | |
| PI | SBP | 2.723 (2.273,3.246) | 0.040 (−0.008,0.092) | NA | NA | 2.908 (2.300,3.400) | 0.041 (0.008,0.099) | 0 | 0 |
| DBP | 1.213 (0.967,1.556) | 0.051 (−0.006,0.134) | NA | NA | 1.305 (0.977,1.614) | 0.052 (−0.001,0.123) | NA | NA | |
| HOMA-IR | SBP | 2.647 (2.055,3.202) | 0.106 (0.064,0.152) | 0.01 | 0.0075 | 3.070 (2.584,3.553) | 0.091 (0.045,0.150) | 0.01 | 0.0075 |
| DBP | 1.115 (0.866,1.406) | 0.169 (0.098,0.262) | 0.01 | 0.0083 | 1.224 (0.961,1.567) | 0.158 (0.101,0.222) | 0.01 | 0.0084 | |
| HOMA-B | SBP | 2.509 (2.011,3.000) | −0.027 (−0.060,−0.006) | 0 | 0 | 2.937 (2.488,3.562) | −0.025 (−0.048,−0.004) | 0 | 0 |
| DBP | 1.098 (0.829,1.344) | 0.002 (−0.033,0.029) | NA | NA | 1.177 (0.881,1.451) | 0.003 (−0.030,0.040) | NA | NA | |
Abbreviation: BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglyceride; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; FG, fasting glucose; PG, 2-h postprandial glucose; FI, fasting insulin; PI, 2-h postprandial insulin.
*Adjusted for age, sex, current smoking, current drinking, exercise regularly, type 2 diabetes, cardiovascular disease, family history of hypertension, and total energy intake. R2*, the proportion of residual variances and , the proportion of original variances that were explained by the omitted confounding.