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. 2017 Jul 14;7:5393. doi: 10.1038/s41598-017-05821-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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sPRE data improve structure determination of RNAs. Structural models of the UUCG tetraloop (a) and the GTP-bound GTP aptamer (b) were obtained without (left) and with (right) sPRE data using XplorNIH. The 10 best scored models (light gray) in terms of total energy were selected from a total of 200 models and aligned to the corresponding NMR structure (magenta). All restraints used in the computations are indicated below the respective models. In (b) heavy atoms of the GTP ligand are shown as sticks (Reference in green, computed models in dark gray) and the positions of the intrinsically flexible nucleotides A13 and U21⁴⁰ are indicated.