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. 2017 Jul 14;7:5506. doi: 10.1038/s41598-017-05421-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ssu72 downregulates Th17 cell differentiation and IL-17 level. (A) CD4⁺ T cells from CIA mice splenocytes were cultured under Th17 conditions for 72 h and then the number of CD4⁺IL-17⁺ cells was quantified. Statistical analyses were conducted using one-way ANOVA with Bonferroni’s post hoc test. (C) Concentration of IL-17 and TNF-α in culture supernatants was measured using ELISA. The data represent the mean ± SD from three independent experiments. Statistical analyses were conducted using the nonparametric Mann-Whitney U-test (*P < 0.05, **P < 0.03, ***P < 0.01, n = 5).