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. 2017 Jul 13;8:16058. doi: 10.1038/ncomms16058

Figure 4. Association between SE-localized sentinel variant rs3557 and thrombus phenotypes.

Figure 4

(a) Chr1 1q23.3 locus view comprising FCER1G and three other genes. From top to bottom: H3K27ac signal track and SE location in MKs (blue) and EBs (red); *position of sentinel variant rs3557 and genes in green. Scale bar in bottom right corner represents 2 kb. Maximum read signal scale 60 for each track. (b) Schematic representation of the glycoprotein (GP)VI/Fc receptor γ-chain signalling receptor complex for collagen on platelets. (c–h) Associations of genotypes of rs1613662 and rs3557 with the residuals of platelet function phenotypes, after adjustment for covariates. Dots show distribution of the phenotypic residuals; central lines show genotype-specific mean estimates and whiskers represent 95% confidence intervals. (c,e) Associations with platelet membrane level of GPVI after linear adjustement for the interaction of logged mean platelet volume and sex (rs1613662: GG=36, GA=221, AA=587, likelihood ratio additive P=1.6 × 10−27; rs3557, TT=696, TG=139, GG=9, likelihood ratio additive P=4.6 × 10−5). (d,f) Associations of fibrinogen binding to integrin αIIbβ3 after platelet activation with CRP-XL, adjusted for sex (rs1613662: GG=49, GA=381, AA=992, likelihood ratio additive P=1.6 × 10−7; rs3557, TT=1,175, TG=229, GG=18, likelihood ratio additive P=4.6 × 10−72). (g,h) Associations for rs1613662 and rs3557 with thrombus formation upon flowing whole blood over collagen III in microchambers, measured by quantile-normalized sex-adjusted platelet surface area coverage (PltSac; GG=1, GA=29, AA=63, likelihood ratio additive P=1.8 × 10−2) and quantile-normalized sex-adjusted activation of integrin αIIbβ3 (ITG; TT=67, TG=24, GG=2, likelihood ratio additive P=3.4 × 10−3), respectively.