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. Author manuscript; available in PMC: 2017 Oct 25.
Published in final edited form as: ACS Nano. 2017 Apr 11;11(4):3875–3882. doi: 10.1021/acsnano.7b00176

Figure 3. Mechanistic studies of nanoprobe nuclear translocation.

Figure 3

a, Near-infrared emission/brightfield overlay images of HeLa cells upon treatment with wheat germ agglutinin (WGA) and guanidinium-nanotube complexes. b, Graph quantifying nuclear localization from the experiment. c, Nuclear localization of nanotubes in cells treated with ivermectin, a pharmacological inhibitor of importin α/β-mediated nuclear import, quantified from NIR fluorescence images. d, Nanotube localization in cells treated with importazole, an inhibitor of importin β-mediated nuclear import. e, Nanotube localization in cells after knockdown of importin β via shRNA transfection. f, Western blot analysis of the shRNA-treated cells. Graphs represent mean ± standard deviation from 3 replicate experiments. ****P<0.0001 (P<0.05 significant).