. 2017 Jul 13;5:e3551. doi: 10.7717/peerj.3551

Table 1. Determination of the IC₅₀values of different chemotherapeutic drugs (tamoxifen, doxorubicin, and cisplatin) on spheroid (3D and 2D conditions) and parental cells of MDA-MB-231.

Serially diluted drugs were added to the cells and MTT assays were performed at 96 h. The 50% inhibition rates of the drugs against the cells were determined from the dose–response curves. Data are expressed as the means value of three experiments replicated with standard deviations (SD). Asterix indicates statistically significant values at p < 0.05. IC₅₀ values of previously published study were also incorporated in the table.

		IC₅₀(µM)
		Tamoxifen	Doxorubicin	Cisplatin
Current study (basal-like derived cells)	MDA-MB-231 Parental	10.28 ± 0.27	0.719 ± 0.13	1.74 ± 0.38
	MDA-MB-231 Spheroid (3D)	37.72 ± 5.31^*	8.083 ± 2.44^*	15.67 ± 1.71^*
	MDA-MB-231 Spheroid (2D)	37.34 ± 3.82^*	12.13 ± 3.61^*	4.00 ± 0.96^*
Published study^a (luminal-like derived cells)	MCF-7 Parental	20.57 ± 2.25	1.00 ± 0.37	2.54 ± 0.44
	MCF-7 Spheroid (3D)	60.73 ± 7.39^*	18.82 ± 3.05^*	13.61 ± 3.54^*
	MCF-7 Spheroid (2D)	47.62 ± 6.83^*	13.25 ± 3.69^*	13.68 ± 3.92^*

Notes.

Adapted from our related published work.

Table 1. Determination of the IC50values of different chemotherapeutic drugs (tamoxifen, doxorubicin, and cisplatin) on spheroid (3D and 2D conditions) and parental cells of MDA-MB-231.

Table 1. Determination of the IC₅₀values of different chemotherapeutic drugs (tamoxifen, doxorubicin, and cisplatin) on spheroid (3D and 2D conditions) and parental cells of MDA-MB-231.