Figure 3. Functional annotation of causal variants.

a, Proportion of credible variants that are protein coding, disrupt/create transcription factor binding motif sites (TFBS) or are synonymous, sorted by posterior probability. b, Epigenetic peaks overlapping credible variants in cell and tissue types from the Roadmap Epigenomics Consortium³⁹. Significant enrichment has been marked with asterisks. Proportion of credible variants that overlap (c) core immune peaks for H4K4me1or (d) core gut peaks for H3K27ac (Methods). In panels a, c and d, the vertical dotted lines mark 50% posterior probability and the horizontal dashed lines show the background proportions of each functional category.