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. Author manuscript; available in PMC: 2017 Dec 28.
Published in final edited form as: Nature. 2017 Jun 28;547(7662):173–178. doi: 10.1038/nature22969

Extended Data Table 2. Colocalization with eQTL.

The number of IBD credible sets that colocalize with eQTLs using the naïve, frequentist and Bayesian approaches. Significant observations are boldfaced. ‘Number of credible sets’ reports the number of credible sets that have MAF above the cut-off.

Tissue/cell line Method Overlaps observed Overlaps Expected P value Dataset MAF cut-off Number of credible sets
whole blood Naïve 3 3.7 0.746 GODOT 0.005 113
whole blood 8 4.2 0.060 Westra 0.05 95
CD14 naïve 8 2.7 0.001 Fairfax 0.04 98
CD14 IFN stimulated 4 3.2 0.398 Fairfax 0.04 98
CD14 LPS 2h stimulated 1 2.1 0.869 Fairfax 0.04 98
CD14 LPS 24h stimulated 5 2.5 0.106 Fairfax 0.04 98
CD4 3 0.4 0.005 ULg 0.05 95
CD8 1 0.3 0.306 ULg 0.05 95
CD14 0 0.2 1.000 ULg 0.05 95
CD15 1 0.2 0.199 ULg 0.05 95
CD19 0 0.1 1.000 ULg 0.05 95
platelets 0 0.0 1.000 ULg 0.05 95
ileum 2 0.3 0.020 ULg 0.05 95
colon 1 0.2 0.202 ULg 0.05 95
rectum 1 0.2 0.189 ULg 0.05 95

CD4 Frequentist 6 1.9 0.013 ULg 0.05 95
CD8 3 1.5 0.186 ULg 0.05 95
CD14 4 2.3 0.180 ULg 0.05 95
CD15 1 1.8 0.863 ULg 0.05 95
CD19 0 1.4 1.000 ULg 0.05 95
platelets 0 0.1 1.000 ULg 0.05 95
ileum 4 1.1 0.018 ULg 0.05 95
colon 3 1.7 0.216 ULg 0.05 95
rectum 4 1.4 0.039 ULg 0.05 95

CD4 Bayesian 4 1.0 0.010 ULg 0.05 95
CD8 1 0.8 0.566 ULg 0.05 95
CD14 1 0.9 0.595 ULg 0.05 95
CD15 0 0.7 1.000 ULg 0.05 95
CD19 0 0.6 1.000 ULg 0.05 95
platelets 0 0.1 1.000 ULg 0.05 95
ileum 2 0.4 0.069 ULg 0.05 95
colon 3 0.8 0.040 ULg 0.05 95
rectum 2 0.6 0.124 ULg 0.05 95