Extended Data Table 2. Colocalization with eQTL.
The number of IBD credible sets that colocalize with eQTLs using the naïve, frequentist and Bayesian approaches. Significant observations are boldfaced. ‘Number of credible sets’ reports the number of credible sets that have MAF above the cut-off.
| Tissue/cell line | Method | Overlaps observed | Overlaps Expected | P value | Dataset | MAF cut-off | Number of credible sets |
|---|---|---|---|---|---|---|---|
| whole blood | Naïve | 3 | 3.7 | 0.746 | GODOT | 0.005 | 113 |
| whole blood | 8 | 4.2 | 0.060 | Westra | 0.05 | 95 | |
| CD14 naïve | 8 | 2.7 | 0.001 | Fairfax | 0.04 | 98 | |
| CD14 IFN stimulated | 4 | 3.2 | 0.398 | Fairfax | 0.04 | 98 | |
| CD14 LPS 2h stimulated | 1 | 2.1 | 0.869 | Fairfax | 0.04 | 98 | |
| CD14 LPS 24h stimulated | 5 | 2.5 | 0.106 | Fairfax | 0.04 | 98 | |
| CD4 | 3 | 0.4 | 0.005 | ULg | 0.05 | 95 | |
| CD8 | 1 | 0.3 | 0.306 | ULg | 0.05 | 95 | |
| CD14 | 0 | 0.2 | 1.000 | ULg | 0.05 | 95 | |
| CD15 | 1 | 0.2 | 0.199 | ULg | 0.05 | 95 | |
| CD19 | 0 | 0.1 | 1.000 | ULg | 0.05 | 95 | |
| platelets | 0 | 0.0 | 1.000 | ULg | 0.05 | 95 | |
| ileum | 2 | 0.3 | 0.020 | ULg | 0.05 | 95 | |
| colon | 1 | 0.2 | 0.202 | ULg | 0.05 | 95 | |
| rectum | 1 | 0.2 | 0.189 | ULg | 0.05 | 95 | |
| CD4 | Frequentist | 6 | 1.9 | 0.013 | ULg | 0.05 | 95 |
| CD8 | 3 | 1.5 | 0.186 | ULg | 0.05 | 95 | |
| CD14 | 4 | 2.3 | 0.180 | ULg | 0.05 | 95 | |
| CD15 | 1 | 1.8 | 0.863 | ULg | 0.05 | 95 | |
| CD19 | 0 | 1.4 | 1.000 | ULg | 0.05 | 95 | |
| platelets | 0 | 0.1 | 1.000 | ULg | 0.05 | 95 | |
| ileum | 4 | 1.1 | 0.018 | ULg | 0.05 | 95 | |
| colon | 3 | 1.7 | 0.216 | ULg | 0.05 | 95 | |
| rectum | 4 | 1.4 | 0.039 | ULg | 0.05 | 95 | |
| CD4 | Bayesian | 4 | 1.0 | 0.010 | ULg | 0.05 | 95 |
| CD8 | 1 | 0.8 | 0.566 | ULg | 0.05 | 95 | |
| CD14 | 1 | 0.9 | 0.595 | ULg | 0.05 | 95 | |
| CD15 | 0 | 0.7 | 1.000 | ULg | 0.05 | 95 | |
| CD19 | 0 | 0.6 | 1.000 | ULg | 0.05 | 95 | |
| platelets | 0 | 0.1 | 1.000 | ULg | 0.05 | 95 | |
| ileum | 2 | 0.4 | 0.069 | ULg | 0.05 | 95 | |
| colon | 3 | 0.8 | 0.040 | ULg | 0.05 | 95 | |
| rectum | 2 | 0.6 | 0.124 | ULg | 0.05 | 95 | |