Table 1.
Final Flavopiridol Pharmacokinetic Model Parameter Estimates
| Parameter | Estimate | %RSE | Bootstrap (200 runs) | |||
|---|---|---|---|---|---|---|
| Estimate | %RSE | 2.5% CI | 97.5% CI | |||
| tvFu (%) | 10.9 | 2.00 | 10.9 | 2.03 | 10.5 | 11.4 |
| tvV (L) | 71.0 | 4.69 | 70.8 | 4.90 | 63.8 | 77.3 |
| tvV2 (L) | 88.8 | 8.34 | 91.4 | 13.6 | 67.4 | 118 |
| tvCl (L/h) | 33.4 | 3.87 | 33.7 | 4.54 | 30.9 | 36.6 |
| tvCl2 (L/h) | 8.95 | 12.3 | 9.28 | 16.2 | 6.40 | 12.5 |
| Prop. RV (total) | 34.9% | 2.04 | 34.7% | 6.26 | 30.5% | 38.3% |
| Prop. RV (unbound) | 34.1% | 2.51 | 33.7% | 5.05 | 30.4% | 37.2% |
| Parameter | Estimate | %RSE | Bootstrap (200 runs) | η Shrinkage | ||
| Estimate | %RSE | |||||
| ηV (%) | 41.0 | 44.3 | 42.7 | 66.2 | 9.79% | |
| ηCl (%) | 48.5 | 37.0 | 47.8 | 45.2 | 4.75% | |
| ηCl2 (%) | 199 | 9.33 | 161 | 26.4 | 5.63% | |
| ηV2 (%) | 98.3 | 22.3 | 100 | 26.5 | 11.2% | |
RSE= relative standard error; CI= confidence interval; Prop. RV = proportional residual variability