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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Kidney Int. 2017 May 12;92(2):336–348. doi: 10.1016/j.kint.2017.02.031

Figure 8. A summative diagram of SCP4 causes muscle wasting in CKD.

Figure 8

CKD and associated inflammation activates NF-kB leading to SCP4 expression. In nucleus, SCP4 dephosphorylates FoxO1/3a and prevents FoxO1/3a nuclear export resulting in atrogrnes expression and increased muscle proteolysis. Therefore, inhibition of SCP4 prevents muscle wasting via the suppression of FoxO1/3a.