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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Kidney Int. 2017 Apr 3;92(2):397–414. doi: 10.1016/j.kint.2017.02.001

Figure 2. Under baseline conditions and after 7 days on low NaCl intake NHE3loxloxCre mice have an impaired urinary concentrating ability in response to 18 hour water deprivation (WD).

Figure 2

(A) WD significantly increased urine osmolality in Con and NHE3loxloxCre mice and remained slightly but significantly lower after 18 hours in NHE3loxloxCre mice; however, (B) the total increase in urine osmolality was comparable between genotypes. (C) Plasma osmolality was comparable under baseline conditions and increased to a similar extent in both genotypes. (D) Body weight changes were comparable between Con and NHE3loxloxCre mice. After 7 days of low NaCl intake, WD significantly increased urine osmolality in both genotypes; however, the increase was significantly lower after 18 hours in NHE3loxloxCre mice. (E) The total increase in urine osmolality was significantly lower in NHE3loxloxCre mice. (F) Possibly as a consequence of the impaired urinary concentrating ability in NHE3loxloxCre mice, plasma osmolality increased to a significantly greater extent and (G) body weight loss tended to be higher in NHE3loxloxCre compared to Con mice. n=7–12/genotype; *P<0.05 versus Con same condition; #P<0.05 versus respective diet same mouse.