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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Kidney Int. 2017 Apr 3;92(2):397–414. doi: 10.1016/j.kint.2017.02.001

Figure 6. Glomerular filtration rate (GFR) is significantly lower in NHE3loxloxCre compared to Con mice.

Figure 6

As shown in Figure 1, baseline GFR was significantly lower in NHE3loxloxCre compared to Con mice. GFR was measured following dietary NaCl challenges for a period of 10 days. (A) Low NaCl intake reduced GFR in both genotypes; in contrast, high NaCl intake was without effect on GFR in either genotype. (B) Representative imaging of Collagen IV staining surrounding the glomerulus did not highlight any clear differences in glomerular structure or size of Bowman’s space between genotypes. *P < 0.05 versus Con same diet, #P < 0.05 versus baseline same mouse, P < 0.05 versus low NaCl diet same genotype.