Fig. 1: A repetitive transcranial magnetic stimulation-oriented theoretical framework of depression involving the left prefrontal cortex (lPFC), the right prefrontal cortex (rPFC), the right parietal cortex (rPC) and the cerebellum (Crbllm). The arrows between the left and right PFC (i) depict the transcallosal inhibitory mechanism, whereas the arrows labelled (ii) represent the functional connectivity between the left PFC and the right parietal cortex. The arrows labelled (iii) denote the cerebellar projections to the PFC, directly via the thalamus and indirectly through dopaminergic activation. Note that the connections represent anatomical interdependencies based on the various neuroscientific methodologies and do not reflect inhibitory or excitatory links per se.