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Structure comparison of PDB 2Q8C (in gold) and KDM4A·Ni(II) (in white) with (E)-JIB-04 docked. (A) Overlay of the two structures shows a high degree of structural similarity. (B) Metal centre and metal-coordinating residue displacements in the two active sites, with (E)-JIB-04 in αKG’s binding site. (C) (E)-JIB-04-binding residues show little displacement between the two structures.
