Table 2.
Summary of cases of patients with SLCT and with RMS elements.
| Case number/case report author | Age | Stage | Initial treatment | Outcome |
|---|---|---|---|---|
| 1/Plastini | 32 | Ia | Local resection | Recurrence at 5 months, then radical hysterectomy followed by 2 cycles of doxorubicin/ifosfamide/vincristine, and then 4 cycles of etoposide/ifosfamide. 10 months later recurrence leads to 3 cycles of BEP. Bleomycin was held for cycles 4 through 8. At 3 and 11 months later it had recurrence treated with radiation. Recurrence at 5 months leads to hospice |
|
| ||||
| 2/Plastini | 30 | Ia | Local resection | Lost to follow-up for 13 months and then repeat surgery for recurrence. Two months later, given 6 cycles of total of doxorubicin/ifosfamide/vincristine. Repeat recurrence, given 6 cycles of irinotecan/temozolomide/vincristine. Further progression with small bowel obstruction requiring debulking surgery and ultimately hospice care |
|
| ||||
| 3/Plastini | 23 | Ia | Debulking surgery, USO, and appendectomy | Sp 6 cycles of doxorubicin, ifosfamide, and vincristine and is currently NED (10 months) |
|
| ||||
| 4/Grove | 29 | Ic | USO | NED at 4 years |
|
| ||||
| 5/Guerard | 16 | Ic | Unilateral oophorectomy | Abdominal deposits at 6–10 months |
|
| ||||
| 6/Kostopoulou | 22 | Ia | Unilateral oophorectomy | NED at 10 months |
|
| ||||
| 7/Rekhi | 17 | Ia | TAH-BSO, omentectomy | Omental deposits at 1 year, lost to follow-up |
|
| ||||
| 8/Chougule | 23 | NS | USO | Unknown |
|
| ||||
| 9/Zaloudek | 16 | Ia | USO | Treated with thiotepa and 5-fluorouracil after recurrence at 1.4 years. Died 4 months later with peritoneal metastases on autopsy |
|
| ||||
| 10/Papler | 70 | Ia | Hysterectomy with LSO, appendectomy, omentectomy, and pelvic and para-aortic lymphadenectomy | Recurrence at 7 months with palliative treatment for symptoms |
|
| ||||
| 11/Prat | 32 | Ia | TAH-RSO | Died 5 months later, found to have peritoneal recurrence |
|
| ||||
| 12/Prat | 22 | Unknown | Unknown | Unknown |
|
| ||||
| 13/Prat | 17 | Ia | LSO | Recurrence in R ovary and pelvis at 6 months leads to TAH-RSO and omentectomy. Second recurrence 3 months later treated with melphalan and resection. Died at 1 year |
|
| ||||
| 14/Prat | 20 | IIa | TAH-BSO | At 5 months found to have peritoneal recurrence treated with resection, doxorubicin, and radiation (7600r.) Died at 10 months |
|
| ||||
| 15/Prat | 36 | IIb | RSO | At 5 months found to have peritoneal recurrence and bowel obstruction. Died at 6 months |
|
| ||||
| 16/Prat | 16 | Ia | RSO | Recurrence in left ovary at 6 months treated with TAH-LSO. Second recurrence at 5 years found in peritoneum treated with resection and questionable chemotherapy. Died at 7 years |
|
| ||||
| 17/Prat | 20 | IIb | RSO, intraabdominal BCG, VAC, and doxorubicin | At 4 months recurrence in cul-de-sac and left ovary treated with TAH-LSO and resection. Second recurrence at 7 months in rectovaginal septum treated with radiation (4600r.) Died at 18 months |
|
| ||||
| 18/Prat | 48 | Ia | TAH-LSO | Not documented |
|
| ||||
| 19/Prat | 23 | Ia | RSO | Recurrence in pelvis and peritoneum at years 1 and 2, respectively, treated with unspecified chemotherapy. Patient alive with tumor at 2-year follow-up |