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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Mov Disord. 2017 May 13;32(7):955–971. doi: 10.1002/mds.27038

Table 2.

Studies that report sensitivity and specificity of brainstem measurements for the diagnosis of PSP-RS compared to other parkinsonian disorders

First author Year Comparison Measure Sensitivity Specificity
Schrag20 2000 35 PSP-RS v 54 MSA MB visual (MB atrophy) 77 37
Adachi14 2004 5 PSP-RS v 23 PD 14 MSA MB visual (morning glory sign) 80 97
Righini25 2004 25 PSP-RS v 27 PD MB visual (superior profile) 68 88.8
Righini25 2004 25 PSP-RS v 27 PD MB visual (MB atrophy) 68 77.7
Price33 2004 12 PSP-RS v (12 PD, 12CN) MB visual (MB atrophy) 83 79
Massey13* 2012 22 PSP v 13 MSA MB visual (MB atrophy) 86.4 66.7
Massey13* 2012 22 PSP v 13 MSA MB visual (Hummingbird) 68.4 100
Oba16 2005 21 PSP-RS v (23 PD, 25 MSA-P, 31 HC) MB area 100 91.3
Cosottini15 2007 15 PSP-RS v (7 MSA-P, 14 CN) MB area 100 90.5
Zanigni17 2016 23 PSP-RS v 42 PD MB area 96 98
Moller32 In Press 106 PSP-RS v 204 PD MB area 84.0 83.8
Moller32 In Press 106 PSP-RS v 60 MSA-P MB area 78.3 81.7
Asato18 2000 8 PSP-RS v 9 MSA-P MB diameter 100 100
Asato18 2000 8 PSP-RS v 21 MSA-C MB diameter 100 91
Schrag20 2000 36 PSP-RS v 54 MSA MB diameter 23 96
Cosottini15 2007 17 PSP-RS v (7 MSA-P, 4 CN) MB diameter 60 95.2
Massey19* 2013 12 PSP-RS v 7 MSA MB diameter 83 100
Kim22 2015 29 PSP-RS v 82 PD MB diameter 50 85.3
Owens21 2016 25 PSP-RS v (25 MSA, 25 PD) MB diameter 44 100
Paviour24 2006 18 PSP-RS v (9 MSA-P, 9 PD, 18 HC) MB volume 72.2 91.9
Paviour24 2006 18 PSP-RS v 9 MSA-P MB volume 83 33
Cosottini15 2007 18 PSP-RS v (7 MSA-P, 14 CN) MB volume 86.7 76.2
Oba16 2005 22 PSP-RS v (23 PD, 25 MSA-P, 31 HC) MB-pons ratio 100 100
Cosottini15 2007 16 PSP-RS v (7 MSA-P, 14 CN) MB-pons ratio 86.7 100
Quattrone38 2008 33 PSP-RS v 108 PD MB-pons ratio 90.9 93.5
Quattrone38 2008 33 PSP-RS v 19 MSA-P MB-pons ratio 97 94.7
Hussl41 2010 22 PSP-RS v 75 PD MB-pons ratio 63.6 94.7
Hussl41 2010 22 PSP-RS v 26 MSA-P MB-pons ratio 63.6 84.6
Morelli37 2011 42 PSP-RS v 170 PD MB-pons ratio 92.9 85.3
Longoni39 2011 10 PSP-RS v 25 PD MB-pons ratio 90 96
Massey19* 2013 13 PSP-RS v 7 MSA MB-pons ratio 67 100
Kim22 2015 30 PSP-RS v 82 PD MB-pons ratio 46.2 89.7
Zanigni17 2016 24 PSP-RS v 42 PD MB-pons ratio 96 90
Owens23 2016 25 PSP-RS v (25 MSA, 25 PD) MB-pons ratio 68 100
Borroni45 2010 18 PSP-RS v (16 CBS, 28 FTD) MB-pons ratio + CSF bio 94.2 84
Sankhla40 2016 20 PSP-RS v 13 PD MB-pons ratio 100 92.86
Moller32 In Press 106 PSP-RS v 204 PD MB-pons ratio 77.4 80.4
Moller32 In Press 106 PSP-RS v 60 MSA-P MB-pons ratio 77.8 89.4
Quattrone38 2008 33 PSP-RS v 108 PD MRPI 100 100
Quattrone38 2008 33 PSP-RS v 19 MSA-P MRPI 100 100
Hussl41 2010 23 PSP-RS v 75 PD MRPI 81.8 76
Hussl41 2010 23 PSP-RS v 26 MSA-P MRPI 81.8 92.3
Morelli37 2011 42 PSP-RS v 170 PD MRPI 100 99.4
Longoni39 2011 10 PSP-RS v 25 PD MRPI 100 92
Kim22 2015 31 PSP-RS v 82 PD MRPI 92.3 39.7
Zanigni17 2016 25 PSP-RS v 42 PD MRPI 87 93
Nigro43 2016 88 PSP-RS v 234 PD MRPI 100 100
Nigro43 2016 88 PSP-RS v 234 PD MRPI (automated) 97.3 97.4
Sankhla40 2016 20 PSP-RS v 13 PD MRPI 100 100
Mostile44 2016 12 PSP-RS v 17 vascular parkinsonism MRPI 100 100
Moller32 In Press 106 PSP-RS v 204 PD MRPI 68.9 67.7
Moller32 In Press 106 PSP-RS v 60 MSA-P MRPI 79.0 64.1

PD = Parkinson's disease; MSA-P = parkinsonian variant of multiple system atrophy; MSA-C = cerebellar variant of multiple system atrophy; CBS = corticobasal syndrome; FTD = frontotemporal dementia; CN = cognitively normal controls; MB = midbrain; MRPI = MR parkinsonism index; CSF bio = cerebrospinal fluid biomarkers

*

Studies with autopsy-confirmed PSP