Table 2.
Germline gene subpanel (v6). Genes in bold represent those 35 Tier 1 genes for which there exist established guidelines/recommendations for management of patients with germline mutations (Tier 1a). The remaining Tier 1 genes form Tier 1b
| Tier‐1 genes (72) | ||||||||
| APC | BRIP1 | FANCA | FANCL | MEN1 | NF2 | PTCH1 | SDHA | SUFU |
| ATM | CDH1 | FANCB | FANCM | MET | NTHL1 | PTCH2 | SDHAF2 | TERT |
| AXIN2 | CDK4 | FANCC | FH | MLH1 | PALB2 | PTEN | SDHB | TMEM127 |
| BAP1 | CDKN1B | FANCD2 | FLCN | MSH2 | PDGFRA | RAD51C | SDHC | TP53 |
| BARD1 | CDKN2A | FANCE | GREM1 | MSH6 | PMS2 | RAD51D | SDHD | TSC1 |
| BMPR1A | CHEK2 | FANCF | KIT | MUTYH | POLD1 | RB1 | SLX4 | TSC2 |
| BRCA1 | EGFR | FANCG | MAX | NBN | POLE | RET | SMAD4 | UBE2T |
| BRCA2 | EPCAM | FANCI | MC1R | NF1 | POT1 | RHBDF2 | STK11 | VHL |
| Tier‐2 genes (76) | ||||||||
| ALK | DIS3L2 | FAH | KHDC3L | PHOX2B | RPL11 | SEC23B | SPINK1 | WT1 |
| BLM | DKC1 | FAS | KRAS | POLH | RPL35A | SERPINA1 | STIM1 | XIAP |
| BRAF | ERCC1 | FASLG | LZTR1 | PRF1 | RPL5 | SH2D1A | TERC | XPA |
| BUB1B | ERCC2 | GPC3 | MNX1 | PRKAR1A | RPS19 | SHOC2 | TINF2 | XPC |
| CBL | ERCC3 | H19 | MTAP | PRSS1 | RPS24 | SLC25A13 | TRIM37 | |
| CDKN1C | ERCC4 | HFE | NHP2 | PTPN11 | RPS7 | SMARCA4 | UNC13D | |
| CYLD | ERCC5 | HRAS | NLRP7 | RAF1 | RTEL1 | SMARCB1 | WNT10A | |
| DDB2 | EXT1 | ITK | NOP10 | RECQL4 | RUNX1 | SOS1 | WRAP53 | |
| DICER1 | EXT2 | KCNQ1OT1 | NSD1 | RIT1 | SBDS | SOS2 | WRN | |