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. 2017 Jul 17;11:205. doi: 10.3389/fncel.2017.00205

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Copyright © 2017 Deng, Xiao, Zhang, Peng, Yuan, Xu, Zhang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of BMSC-EVs on 5 min of bilateral common carotid artery occlusion-induced COX-2 expression at mRNA and protein levels in the hippocampi. Intracerebroventricular injection (ICVI) of 200 μg BMSC-EVs right before occlusion largely suppressed pathogenic expression of COX-2 at (A) mRNA level (sham + EV = 96 ± 4, ischemia = 5.7 ± 1.5, ischemia + EV = 2.2 ± 0.7) and (B) protein level (sham + EV = 1.2 ± 0.15, ischemia = 341 ± 39, ischemia + EV = 128 ± 10). n = 8 tests per group. Data show means ± SEM. One-way ANOVA analysis followed by a Tukey’s post hoc test. **p < 0.01 and ***p < 0.001.