Table 3.

The association between creatinine-adjusted urinary osteopontin and plasma osteopontin and cardiovascular mortality (Cox regression)

	Cardiovascular mortality
	urinary osteopontin, ng/mL		plasma osteopontin, ng/mL
	HR (95% CI)	p value	HR (95% CI)	p value
Model A	0.98 (0.78 – 1.21)	0.82	1.55 (1.35 – 1.76)	<0.001
Model B	1.03 (0.83 – 1.29)	0.77	1.41 (1.22 – 1.63)	<0.001
Model C	1.00 (0.80 – 1.24)	0.97	1.44 (1.25 – 1.67)	<0.001
Model D	0.90 (0.72 – 1.12)	0.34	1.51 (1.31 – 1.74)	<0.001
Model E	1.00 (0.79 – 1.26)	0.99	1.35 (1.14 – 1.58)	<0.001

Data are HR per standard deviation increment. Plasma osteopontin, n = 739; urinary osteopontin, n = 513. HR, hazard ratio; CI, confidence interval; model A, age-adjusted model; model B, kidney function model (model A + cystatin C-estimated glomerular filtration rate and albuminuria); model C, inflammation model (model A + C-reactive protein and interleukin 6); model D, cardiovascular risk factor model (model A + lipid-lowering treatment, cardiovascular diagnosis, body mass index, diabetes, antihypertensive treatments, systolic blood pressure, high-density lipoprotein cholesterol, total cholesterol, and smoking); model E, total model (combination of all variables included in model A–D).