Table 5.
Genotype distribution differences of MTHFR 677C>T, MTHFR 1298A>C, and MTRR 66A>G polymorphisms between control and CHD (VSD and non-VSD) mothers.
| MTHFR 677C>T | MTHFR 1298A>C | MTRR 66A>G | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | AA | AC | CC | AA | AG | GG | |
| Control | 36 (31.6) | 48 (42.1) | 30 (26.3) | 89 (78.1) | 24 (21.1) | 1 (0.8) | 67 (58.8) | 44 (38.6) | 3 (2.6) |
| Non-VSD | 12 (15.4) | 33 (42.3) | 33 (42.3) | 57 (73.1) | 21 (26.9) | 0 (0) | 37 (47.4) | 35 (44.9) | 6 (7.7) |
| VSD | 8 (38.1) | 8 (38.1) | 5 (23.8) | 14 (66.7) | 7 (33.3) | 0 (0) | 7 (33.3) | 11 (52.4) | 3 (14.3) |
| Non-VSD versus control | χ2 | 3.288 | 8.473 | 0.828 | 0.638 | 1.433 | 3.396 | ||
| P | 0.070 | 0.004 | 0.363 | 1.000 | 0.231 | 0.138 | |||
| OR | 2.063 | 3.300 | 1.366 | 0.989 | 1.440 | 3.622 | |||
| 95% CI | 0.937–4.542 | 1.454–7.488 | 0.697–2.679 | 0.967–1.011 | 0.792–2.621 | 0.856–15.330 | |||
| VSD versus control | χ2 | 0.278 | 0.215 | 1.457 | 0.157 | 2.92 | 8.340 | ||
| P | 0.598 | 0.643 | 0.227 | 1.000 | 0.088 | 0.004 | |||
| OR | 0.750 | 0.750 | 1.854 | 2.393 | 9.571 | ||||
| 95% CI | 0.257–2.189 | 0.222–2.535 | 0.673–5.107 | 0.862–6.643 | 1.615–56.736 | ||||