Table 6.
Genotype distribution differences of MTHFR 677C>T, MTHFR 1298A>C, and MTRR 66A>G polymorphisms between control and CHD (VSD and non-VSD) fathers.
| MTHFR 677C>T | MTHFR 1298A>C | MTRR 66A>G | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CC | CT | TT | AA | AC | CC | AA | AG | GG | |
| Control | 37 (32.5) | 47 (41.2) | 30 (26.3) | 82 (71.9) | 31 (27.2) | 1 (0.9) | 68 (59.6) | 44 (38.6) | 2 (1.8) |
| Non-VSD | 12 (15.4) | 39 (50.0) | 27 (34.6) | 55 (70.5) | 21 (26.9) | 2 (2.6) | 47 (60.2) | 25 (32.1) | 6 (7.7) |
| VSD | 8 (38.1) | 9 (42.9) | 4 (19.0) | 16 (76.2) | 4 (19.0) | 1 (4.8) | 7 (33.3) | 12 (57.1) | 2 (9.5) |
| Non-VSD versus control | χ2 | 5.778 | 5.931 | 0.001 | 0.855 | 0.389 | 3.553 | ||
| P | 0.016 | 0.015 | 0.976 | 0.741 | 0.533 | 0.130 | |||
| OR | 2.559 | 2.775 | 1.010 | 2.982 | 0.822 | 4.340 | |||
| 95% CI | 1.176–5.566 | 1.206–6.385 | 0.527–1.936 | 0.264–33.689 | 0.444–1.522 | 0.839–22.441 | |||
| VSD versus control | χ2 | 0.052 | 0.544 | 0.484 | 1.575 | 3.782 | 6.221 | ||
| P | 0.820 | 0.461 | 0.487 | 0.313 | 0.078 | 0.013 | |||
| OR | 0.886 | 0.617 | 0.661 | 5.125 | 2.649 | 9.714 | |||
| 95% CI | 0.311–2.519 | 0.169–2.247 | 0.205–2.133 | 0.305–86.248 | 0.968–7.247 | 1.179–80.024 | |||