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Working model for maturation of the large subunit into functional [NiFe]-hydrogenase. i, incorporation of the Fe(CN)2CO moiety into the hydrogenase large subunit (pro-protein) by the coordinated activity of HypCDEF. ii, nickel insertion by concerted activity of HypA, HypB, and SlyD. iii, endoproteolytic cleavage of the C-terminal peptide, associated with conformational changes of the protein. iv, dimerization of large and small subunit forms functional [NiFe]-hydrogenase.
