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A, Representative traces showing whole-cell currents activated by EC30 GABA (0.5 μM) recorded from HEK293 cells transiently expressing α1β2 GABAA receptors. Efavirenz (1–30 μM) was co-applied with GABA for 10 sec. B, A Summary data showing the efavirenz concentration-response relationship. All currents are normalized to the response to 0.5 μM GABA. *, p<0.05; **, p<0.01, paired t-test, compared to the control, n=5–6.
