Table 1.
GABA sensitivity of different GABAA receptor configurations
Receptor configurations | EC50 (μM) | Hill coefficient | Sample size | EC30 (μM) |
---|---|---|---|---|
α1β2γ 2 | 34 ± 4.9 | 1.08 ± 0.15 | 8 | 10 |
α2β2γ2 | 40 ± 2.3 | 1.48 ± 0.11 | 6 | 23 |
α3β2γ21 | 33 ± 2.1 | 1.1 ± 0.03 | 4 | 20 |
α4β2γ2 | 4.3 ± 0.2 | 1.19 ±0.05 | 5 | 2 |
α5β2γ2 | 16 ± 1.0 | 1.27 ± 0.09 | 4 | 9 |
α6β2γ21 | 1.6 ± 0.1 | 1.6 ± 0.11 | 4 | 1 |
α1β22 | 1.6 ± 0.2 | 1.3 ± 0.10 | 4 | 0.5 |
α1(T6′F)β22 | 1.7 ± 0.3 | 0.9 ± 0.10 | 4 | 0.5 |
α1β2(T6′F)2 | 3.6 ± 0.5 | 1.1 ± 0.10 | 4 | 1.2 |
α1(R84P)β2γ2 | 7.9 ± 1.2 | 1.54 ± 0.21 | 7 | 4 |
α1(M89L)β2γ2 | 6.6 ± 0.5 | 1.50 ± 0.08 | 4 | 4 |
α1(I120L)β2γ2 | 32 ± 1.0 | 1.17 ±0.04 | 5 | 10 |
α1(R84P/M89L)β2γ2 | 4.1 ± 0.1 | 0.93 ± 0.03 | 5 | 1.7 |
α1(R84P/M89L/I120L)β2γ2 | 5.3 ± 0.4 | 1.24 ± 0.09 | 4 | 2.5 |
1, 2. indicate the values reported in our previous publications: