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. 2016 Nov 14;66(7):1286–1296. doi: 10.1136/gutjnl-2016-312268

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Loss of retinoblastoma (RB1) confers resistance to palbociclib (PD) in human liver cancer cell lines. (A) Proliferation of cells, relative to control cells treated with dimethyl sulfoxide (DMSO), at different time points. (B) Immunoblotting analysis of indicated proteins at the end of the experiment in (A). The dashed line separates different portions of the same gel. (C) Dose–response curves for different doses of PD and cells infected with different shRNAs. (D) Crystal violet staining of colonies from a representative cell line infected with control or RB1 shRNAs and treated during 2 weeks with the indicated doses of PD. (E) Immunoblotting analysis of indicated proteins (basal levels) of cells in (C). c, control. 1–4 represent the different single-guide RNAs for RB1.