Table 5.

Tubulin polymerization inhibition, docking energy values and correlative data for representative lignans and hybrid compounds of this research.

Compd.	Leishmania tubulin polymerization inhibition (IC50 μM)	Docking energy Leishmania (kcal/mol)	Docking energy Bos taurus (kcal/mol)
2a	0.32 ± 0.03	−9.0	−8.0
5a	1.14 ± 0.14	−8.9	−7.7
14	2.05 ± 0.32	−7.5	−7.4
15	0.75 ± 0.04	−7.9	−7.9
21	2.02 ± 0.02	−7.4	−7.4
23	9.92 ± 0.55	−10.2	−7.9
31	1.16 ± 0.06	−8.4	−8.8
34	0.78 ± 0.04	−7.8	−9.1
35	1.64 ± 0.18	−8.5	−8.4
40	1.51 ± 0,05	−8.3	−8.3
46	0.66 ± 0.01	−8.4	−10.3
48	1.32 ± 0,01	−9.8	−7.1
49	0.31 ± 0.01	−9.2	−10.3
Colchicine	>100	df	−10.3

df: docking failure.