TABLE 1.
NY/108 virus virulence in ferrets
| Routea | Doseb (EID50) | No. of infected ferrets/total no.c | % wt lossd | Rise in tempe (°C) | Peak titer in NWf | No. of ferrets/total no.g: |
No. of ferrets that seroconverted/total no.h | |
|---|---|---|---|---|---|---|---|---|
| CW | RS | |||||||
| i.n. | 106 | 6/6 | 4.9 | 0.6 | 7.0 ± 0.8 (1–3) | 1/6 | 0/6 | 6/6 (160–640) |
| AR | 105.7 | 3/3 | 7.3 | 1.2 | 6.2 ± 0.6 (3–5) | 0/3 | 2/3 | 3/3 (320–640) |
| AR | 103.5 | 1/3 | 7.0 | 0.8 | 5.8 (5) | 0/3 | 0/3 | 1/3 (320) |
| OA | 102.9–103.6 | 2/3 | 8.0 | 0.9 | 6.0 ± 0.4 (7) | 1/3 | 1/3 | 2/3 (160–320) |
i.n., 1 ml liquid intranasal administration; AR, aerosol inhalation; OA, ocular aerosol exposure.
The specific aerosol dosing information is presented in the table in Fig. 2.
Number of ferrets with positive virus detection in nasal wash and seroconversion against homologous virus by the end of experiment/total number of ferrets tested.
Mean maximum weight loss observed among all infected ferrets through day 10 p.i.
Mean maximum rise in body temperature among all infected ferrets through day 10 p.i.
Mean maximum viral titer detected in nasal wash (NW) samples ± standard deviation. The day(s) of peak virus detection is specified in parentheses.
Number of ferrets with positive virus detection in conjunctival wash (CW) or rectal swab (RS) samples through day 5 p.i./total number of ferrets tested. The limits of virus detection were 100.8 EID50 and 101.5 EID50 for CW and RS samples, respectively.
Number of ferrets that seroconverted to homologous virus/total number of ferrets tested. The range of the hemagglutination inhibition titers is specified in parentheses.