TABLE 1.
Most abundantly detected (top 25%) conserved protein partners of JUNV Candid #1 and LCMV Armstrong 53b NPsa
| Gene symbol | Gene description | IPI ID | Peptide spectral count |
|
|---|---|---|---|---|
| JUNV | LCMV | |||
| AIFM1 | Programmed cell death 8 (apoptosis-inducing factor) | IPI00000690 | 89 | 3 |
| ASPH | Aspartate beta-hydroxylase | IPI00294834 | 23 | 8 |
| CCT6A | Chaperonin containing TCP1, subunit 6A (zeta 1) | IPI00027626 | 43 | 3 |
| CCT7 | Chaperonin containing TCP1, subunit 7 (eta) | IPI00018465 | 40 | 4 |
| CKAP4 | Cytoskeleton-associated protein 4 | IPI00141318 | 22 | 9 |
| CKAP5 | Cytoskeleton-associated protein 5 | IPI00028275 | 13 | 12 |
| CLTC | Clathrin, heavy polypeptide (Hc) | IPI00024067 | 19 | 18 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked | IPI00215637 | 18 | 18 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | IPI00017617 | 12 | 24 |
| DHX9 | DEAH box helicase 9 | IPI00844578 | 32 | 27 |
| EEF1A2 | Eukaryotic translation elongation factor 1 alpha 2 | IPI00014424 | 16 | 8 |
| FLNA | Filamin A, alpha (actin binding protein 280) | IPI00302592 | 16 | 77 |
| FLNB | Filamin B, beta (actin binding protein 278) | IPI00289334 | 13 | 21 |
| HADHA | Hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase (trifunctional protein), alpha subunit | IPI00031522 | 22 | 15 |
| HIST2H2BE | Histone 2, H2be | IPI00003935 | 8 | 39 |
| HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1 | IPI00215965 | 13 | 16 |
| HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1 | IPI00396378 | 17 | 12 |
| HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A2/B1 | IPI00386854 | 3 | 27 |
| HNRNPK | Heterogeneous nuclear ribonucleoprotein K | IPI00216049 | 24 | 15 |
| HNRNPM | Heterogeneous nuclear ribonucleoprotein M | IPI00171903 | 25 | 32 |
| HNRNPU | Heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | IPI00479217 | 15 | 12 |
| HSPA8 | Heat shock 70-kDa protein 8 | IPI00003865 | 31 | 18 |
| IGF2BP1 | Insulin-like growth factor 2 mRNA binding protein 1 | IPI00008557 | 20 | 19 |
| ILF2 | Interleukin enhancer binding factor 2, 45 kDa | IPI00005198 | 12 | 19 |
| IQGAP1 | IQ motif-containing GTPase activating protein 1 | IPI00009342 | 14 | 20 |
| KIAA1618 | Chromosome 17 open reading frame 27 | IPI00642126 | 76 | 3 |
| LMNA | Lamin A/C | IPI00021405 | 31 | 105 |
| MAP1B | Microtubule-associated protein 1B | IPI00008868 | 14 | 10 |
| MATR3 | Matrin 3 | IPI00017297 | 12 | 20 |
| MOV10 | Mov10, Moloney leukemia virus 10, homolog (mouse) | IPI00444452 | 17 | 16 |
| MYBBP1A | MYB binding protein (P160) 1a | IPI00005024 | 28 | 6 |
| MYO1B | Myosin IB | IPI00376344 | 10 | 30 |
| MYO1C | Myosin IC | IPI00010418 | 27 | 55 |
| MYO6 | Myosin VI | IPI00008455 | 9 | 18 |
| NCL | Nucleolin | IPI00183526 | 22 | 17 |
| NCL | Nucleolin | IPI00444262 | 22 | 13 |
| NPM1 | Anaplastic lymphoma kinase (Ki-1) | IPI00220740 | 14 | 26 |
| PABPC1 | Poly(A) binding protein, cytoplasmic 1 | IPI00008524 | 29 | 39 |
| PARP1 | Poly(ADP-ribose) polymerase family, member 1 | IPI00449049 | 24 | 30 |
| PLEC1 | Plectin 1, intermediate filament binding protein, 500 kDa | IPI00014898 | 55 | 307 |
| PKR | Double-stranded RNA-activated protein kinase (eukaryotic translation initiation factor 2 alpha kinase 2) | IPI00019463 | 18 | 7 |
| PRKDC | Protein kinase, DNA activated, catalytic polypeptide | IPI00296337 | 60 | 46 |
| RPL10A | Ribosomal protein L10a | IPI00412579 | 15 | 12 |
| RPL12 | Ribosomal protein L12 | IPI00024933 | 15 | 11 |
| RPL13P12 | Ribosomal protein L13 pseudogene 12 | IPI00397611 | 13 | 13 |
| RPL23 | Ribosomal protein L23 | IPI00010153 | 14 | 19 |
| RPL23A | Ribosomal protein L23a | IPI00021266 | 12 | 15 |
| RPL3 | Ribosomal protein L3 | IPI00550021 | 19 | 14 |
| RPL4 | Ribosomal protein L4 | IPI00003918 | 20 | 9 |
| RPL5 | Ribosomal protein L5 | IPI00000494 | 22 | 17 |
| RPL6 | Ribosomal protein L6 | IPI00329389 | 25 | 28 |
| RPL7 | Ribosomal protein L7 | IPI00030179 | 14 | 18 |
| RPL7A | Ribosomal protein L7a | IPI00299573 | 16 | 17 |
| RPLP0 | Ribosomal protein, large, P0 | IPI00008530 | 39 | 31 |
| RPLP2 | Ribosomal protein, large, P2 | IPI00008529 | 22 | 15 |
| RPS18 | Ribosomal protein S18 | IPI00013296 | 12 | 14 |
| RPS19 | Ribosomal protein S19 | IPI00215780 | 9 | 21 |
| RPS3 | Ribosomal protein S3 | IPI00011253 | 14 | 31 |
| RPS3A | Ribosomal protein S3A | IPI00419880 | 11 | 20 |
| RPS4X | Ribosomal protein S4, X-linked | IPI00217030 | 13 | 22 |
| RRBP1 | Ribosome binding protein 1 homolog, 180 kDa (dog) | IPI00215743 | 40 | 6 |
| SFPQ | Splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated) | IPI00010740 | 17 | 16 |
| SLC25A5 | Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | IPI00007188 | 27 | 27 |
| TMPO | Thymopoietin | IPI00030131 | 9 | 43 |
| TMPO | Thymopoietin | IPI00216230 | 4 | 34 |
| TUBB2C | Tubulin, beta 2C | IPI00007752 | 14 | 8 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining, Ku autoantigen, 80 kDa) | IPI00220834 | 14 | 13 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70 kDa) | IPI00644712 | 15 | 18 |
a
The most abundant interactors were defined as those having the largest average numbers of spectral counts (total peptides) from the JUNV (n = 8 independent experiments) or LCMV (n = 4 independent experiments) mass spectrometry experiments.