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Virus titers in organs following RRVVP4-R446G injection. (A) Viral titers from extrahepatic bile ducts harvested at 1 and 7 days postinfection were both significantly lower for mice injected with RRVVP4-R446G than for those injected with RRV or RRVVP4-XbaI (n = 6 per group). (B) Similarly, RRVVP4-R446G-injected mice expressed significantly lower viral titers in the intestine at 7 days postinfection than those for RRV-injected mice. *, P < 0.05.
