TABLE 6.
Serum neutralizing antibodies against homologous and heterologous H5 viruses in ferrets immunized with the Egy/09 ca and dk/Hok/00 ca vaccines
| Vaccine virus | Days after 1st dose (days after 2nd dose) | GMT (95% CI)a |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| ck/Egy/10 (H5N1) | Indo/05/05 (H5N1) | Viet/1203/04 (H5N1) | ck/PA/83 (H5N2) | AGW/WA/14 (H5N1) | NP/WA/14 (H5N2) | gyrfal/WA/14 (H5N8) | dk/Hok/00 (H5N3) | ||
| Egy/09 ca | 14 | ≤10 | ≤10 | ND | ≤10 | ND | ND | ND | ≤10 |
| 27b | ≤10 | ≤10 | ND | ≤10 | ND | ND | ND | ≤10 | |
| 42 (14) | 259 (167–398) | 160 (79–324) | 23 (16–32) | 58 (18–185) | 20 (NA) | ≤10 | ≤10 | 95 (37–247) | |
| 52 (24) | 206 (112–379) | 58 (28–119) | 32 (NA) | 28 (13–62) | ≤10 | ≤10 | ≤10 | 44 (19–101) | |
| dk/Hok/00 ca | 14 | ≤10 | ≤10 | ND | ≤10 | ND | ND | ND | <10 |
| 27b | ≤10 | ≤10 | ND | 18 (14–24) | ND | ND | ND | 92 (55–153) | |
| 42 (14) | 93 (55–159) | ≤10 | ≤10 | 115 (63–210) | 29 (16–53) | 72 (37–142) | 65 (33–128) | 581 (334–1,013) | |
| 52 (24) | 90 (57–142) | ≤10 | ≤10 | 70 (27–184) | 25 (21–30) | 64 (27–148) | 51 (25–106) | 411 (181–933) | |
a
Shown are geometric mean titers (95% confidence intervals [CI]) of data from 6 ferrets. ND, not done; NA, not applicable (only one animal had a measurable titer of ≥10). Prevaccination sera had no detectable antibody.
b
One day before the second dose was administered.