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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Epilepsy Res. 2017 Apr 30;134:1–8. doi: 10.1016/j.eplepsyres.2017.04.020

Figure 1. Interictal and ictal EEG s in Gabrg2+/Q390X knockin mice.

Figure 1

(A) Representative EEG recordings show that a 2 month old Gabrg2+/Q390X knockin mouse had spike-wave-discharges (SWDs). (B) The frequency of SWDs in Gabrg2+/Q390X mice was 4–7 Hz. (C) Spontaneous generalized tonic clonic seizures (GTCSs) were associated with epileptiform activity on EEG (D). Spontaneous myoclonic jerks were associated with spike discharges on EEG. (E) Average occurrences of GTCSs and myoclonic jerks (MJ) with noticeable behavioral seizures over 24 hours EEG recordings were measured in 2–4 month old mice (n = 31 for each genotype). (F,G) The pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α) (F) or interleukin-1beta (IL-1β) (G) in 50 µl plasma from peripheral blood of mice untreated or treated at 42.5C for 30 min were measured with Elisa.