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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Epilepsy Res. 2017 Apr 30;134:1–8. doi: 10.1016/j.eplepsyres.2017.04.020

Figure 2. Temperature elevation and PTZ induced seizures and abnormal EEGs in Gabrg2+/Q390X knockin mice.

Figure 2

(A) The temperature induction apparatus and heating setup are shown. (B) A diagram of the temperature induction and pentylenetetrazol (PTZ) seizure induction procedures are shown. (C) Sample EEGs traces are shown for 2–4 month old Gabrg2+/(Q390X) knockin mice during temperature elevation. (D) Sample EEGs traces are shown for 2–4 month old Gabrg2+/(Q390X) knockin mice during PTZ seizure induction. (E) Number of myoclonic jerks for 2–4 month old wild-type (wt) and Gabrg2+/Q390X knockin (het) mice are plotted for baseline and for temperature elevation and PTZ seizure induction segments. (F) Frequency of SWDs for 2–4 month old wild-type (wt) and Gabrg2+/Q390X knockin (het) mice are plotted for baseline, temperature induction, and PTZ segments. (Temperature seizure induction, n = 10 for wt and 10 for het; PTZ seizure induction, n = 6 for wt and 10 for het) (***p < 0.001 vs wt); (†† p < 0.01; ††† p < 0.001 vs baseline het).