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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Epilepsy Res. 2017 Apr 30;134:1–8. doi: 10.1016/j.eplepsyres.2017.04.020

Figure 4. Heat induced body temperature changes as well as seizures and anxiety-like phenotypes were differentially expressed in Gabrg2+/Q390X mice at different age.

Figure 4

(A) The percentage of mice to reach 42.5 °C during temperature induction was plotted for P18–20 and 2–4 month old wild-type (wt) and Gabrg2+/Q390X knockin (het) mice. (B) The rate of core body temperature change assessed over 2-minute intervals during temperature induction was plotted for P18–20 and 2–4 month old wild-type (wt) and Gabrg2+/Q390X knockin (het) mice. (C) The number of myoclonic jerks during temperature induction was plotted for P18–20 and 2–4 month old wild-type (wt) and Gabrg2+/Q390X knockin (het) mice. (D) The number of GTCS (GTCSs) during temperature induction was plotted for P18–20 and 2–4 month old wild-type (wt) and Gabrg2+/Q390X (het) mice. (E) Frequency of jumping bouts during temperature induction was plotted for P18–20 and 2–4 month old wild-type (wt) and Gabrg2+/Q390X knockin (het) mice (n = 10 for wt and het for 2–4 month old mice; n = 11 for wt and 14 for het for P18–20); (*p < 0.05 vs wt).