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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Nov 9;65:69–79. doi: 10.1016/j.semcdb.2016.11.002

Fig. 1.

Fig. 1

Schematic diagram of miRNA biogenesis and epigenetic mechanisms in the mammalian cell. Common histone PMTs such as histone methylation (me) and acetylation (ac) are indicated. DNA methylation is shown on the DNA double helix, as 5-MeC and CH3. Gene transcription produces a pri-miRNA that is processed by Drosha to form a pre-miRNA. Exportin-5 facilitates its export to the cytoplasm, where Dicer cleaves the pre-miRNA into short double-stranded RNA. The RISC complex is activated and its catalytic component argonaute (Ago) leads to degradation of mRNA, translational suppression and deadenylation.