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Changes in the proportion of CD8+ T cells expressing exhaustion markers across all CD8+ T cell subsets. The expression of four T cell exhaustion markers (PD-1, TIGIT, CD160, and 2B4) was evaluated by flow cytometry on peripheral blood CD8+ T cell subsets, as described in Figure 1. The proportion of cells that are positive for a given marker (%marker+) is shown. *p < .05, **p < .01.
