Table 2.
Plasma Amino Acid Concentrations for HIV-Infected Subjects Compared to Healthy Controls
| Median (Q1, Q3) μmol/L | Controls (N = 40) | High CD4 (N = 40) | Low CD4a(N = 39) | pb | All HIV+(N = 79) | pc |
|---|---|---|---|---|---|---|
| Total amino acids | 2,565 (2,431, 2,853) | 2,408 (2,146, 2,603) | 2,388 (2,181, 2,628) | .19 | 2,404 (1,698, 4,244) | .002 |
| Essential amino acids | 855 (800, 920) | 791 (683, 893) | 747 (657, 856) | .22 | 771 (535, 1,882) | <.001 |
| Branched-chain amino acids | 387 (338, 431) | 352 (306, 411) | 338 (294, 365) | .26 | 345 (213, 1,014) | .004 |
| Sulfur amino acids | 44 (33, 50) | 39 (30, 48) | 37 (29, 44) | .12 | 37 (21, 77) | .020 |
| Methionine | 25 (21, 27) | 20 (18, 23) | 20 (15, 22) | .03 | 20 (17, 23) | <.001 |
| Leucine | 117 (103, 130) | 109 (93, 127) | 97 (88, 115) | .24 | 103 (90, 116) | .001 |
| Citrulline | 32 (27, 34) | 29 (23, 33) | 27 (24, 30) | .02 | 27 (24, 33) | .002 |
| Valine | 215 (186, 237) | 193 (167, 224) | 185 (157, 208) | .20 | 186 (160, 217) | .004 |
| Proline | 168 (145, 185) | 147 (119, 174) | 139 (121, 176) | .33 | 143 (120, 175) | .005 |
| Aspartate | 5 (4, 6) | 4 (3, 6) | 4 (3, 6) | .04 | 4 (3, 6) | .009 |
| Glutamine | 529 (479, 583) | 459 (411, 538) | 498 (451, 554) | .07 | 481 (430, 552) | .011 |
| Lysine | 170 (148, 191) | 157 (132, 175) | 156 (138, 172) | .46 | 156 (136, 173) | .012 |
| Threonine | 135 (121, 173) | 129 (101, 152) | 131 (100, 160) | .09 | 129 (101, 155) | .013 |
| Tyrosine | 61 (53, 72) | 56 (46, 75) | 53 (42, 59) | .046 | 54 (45, 63) | .020 |
| Phenylalanine | 48 (43, 52) | 43 (39, 50) | 45 (40, 50) | .40 | 44 (40, 50) | .021 |
| Isoleucine | 58 (52, 66) | 54 (49, 67) | 52 (46, 60) | .28 | 53 (48, 63) | .045 |
| Serine | 114 (100, 130) | 108 (97, 115) | 103 (89, 125) | .18 | 105 (94, 121) | .057 |
| Alanine | 338 (306, 401) | 339 (280, 370) | 295 (242, 375) | .16 | 319 (255, 373) | .068 |
| Arginine | 51 (41, 65) | 44 (32, 57) | 50 (37, 66) | .37 | 45 (36, 62) | .091 |
| Histidine | 75 (71, 85) | 76 (72, 83) | 74 (66, 79) | .32 | 74 (66, 82) | .210 |
| Glycine | 259 (225, 308) | 252 (223, 278) | 265 (227, 288) | .69 | 258 (226, 285) | .482 |
| Ornithine | 76 (65, 102) | 77 (63, 103) | 72 (59, 89) | .33 | 72 (60, 94) | .555 |
| Cysteine | 19 (10, 26) | 17 (11, 24) | 16 (10, 23) | .90 | 16 (11, 24) | .589 |
| Glutamate | 60 (28, 78) | 71 (45, 91) | 70 (54, 81) | .08 | 71 (53, 88) | .022 |
Boldfaced p values indicate those <.05.
a
There were no p values <.05 for the comparison of HIV+ subjects with a high versus low CD4 count.
b
Comparison of the three groups (healthy controls, HIV+ with high CD4, and HIV+ with low CD4).
c
Comparison of all HIV+ subjects combined versus healthy controls).