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. 2016 Sep 13;49(3):627–634. doi: 10.4143/crt.2016.292

Fig. 1.

Fig. 1.

Unclassified variant c.5339T>C in BRCA1. The candidate UV, c.5339T>C, was tested in breast cancer patients and family members (A, B). Red in each pedigree indicates a carrier of the variant genotype, while green indicates family members without the variant. The proband of each family is indicated by a black arrow. (C) Predicted structure of BRCA1 variant (Leu1780Pro) in the BRCA1 C-terminal (BRCT) domain. Left, overall structure of the BRCT domain of BRCA1; right, detailed view of the region surrounding the variant. Hydrophobic residues around Leu1780 are shown and labeled in red.