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. 1980 Sep;29(3):1050–1054. doi: 10.1128/iai.29.3.1050-1054.1980

Antivirus antibody-dependent cell-mediated cytotoxicity during murine cytomegalovirus infection.

J E Manischewitz, G V Quinnan Jr
PMCID: PMC551237  PMID: 6253395

Abstract

BALB/c mice infected with murine cytomegalovirus were studied to determine whether antibody-dependent cell-mediated cytotoxicity contributes to the immune control of this infection. Antibody-dependent killer cells from uninfected mice were used as effector cells to assay for antibody in sera of infected mice. Secondary immune sera were found to contain both cytomegalovirus-specific and autoreactive antibodies. After primary infection only cytomegalovirus-specific antibodies were found. These were detected by antibody-dependent cell-mediated cytotoxicity within 8 to 10 days after onset of infection, but usually not until day 21, by a neutralizing antibody assay. Antibody titers were about 10-fold higher by antibody-dependent cell-mediated cytotoxicity than by neutralization. The results indicate that cellular immunity to cytomegalovirus infection includes an antibody-dependent cell-mediated cytotoxicity response which is likely to be highly efficient and may contribute significantly to control of both acute and later stages of infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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