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Schematic of possible outcomes of CRISPR-Cas9-induced DSBs. Repairing via non-homologous end joining (NHEJ) generates indels, while repair via homologous recombination in the presence of an appropriate donor fragment can be used to introduce specific genetic changes (in orange). The sequence recognized by the sgRNA is in red. The location of the protospacer adjavent motif (PAM) in the target site is also shown.
