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. Author manuscript; available in PMC: 2017 Jul 17.
Published in final edited form as: Curr Opin Clin Nutr Metab Care. 2015 May;18(3):263–268. doi: 10.1097/MCO.0000000000000159

FIGURE 1.

FIGURE 1

Schematic illustration of the strategy used to discover ursolic acid and tomatidine as small molecule inhibitors of muscle atrophy. We compared two mRNA expression signatures of skeletal muscle atrophy with mRNA expression signatures of 1309 small molecules in the Connectivity Map, searching for negative correlations. We found that the mRNA expression signatures of ursolic acid and tomatidine negatively correlated to both muscle atrophy signatures, and then used mouse models to discover that ursolic acid and tomatidine reduce muscle atrophy and increase strength, endurance and muscle mass.