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. 2017 Jul 17;8:806. doi: 10.3389/fimmu.2017.00806

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Copyright © 2017 Theron, Bentley, Nagel, Manchester, Gerg, Schindler, Silva, Ecabert, Teixeira, Perret and Reis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection of Lip10 accumulation by flow cytometry in cynomolgus monkeys after oral administration of RO5459072. (A) Lip10 accumulation in B cells of six cynomolgus monkeys at baseline, after in vitro incubation of PBMC with a serial titration of cathepsin S inhibitor RO5459072. Curve fit was determined by non-linear regression using a variable slope model with GraphPad Prism software. (B) Detection of Lip10 accumulation in circulating B cells from six cynomolgus monkeys, measured by flow cytometry in PBMC enriched from whole blood samples taken at baseline (0 h) and after oral administration of 50 or 200 mg/kg cathepsin S inhibitor RO5459072 (3–72 h).