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. Author manuscript; available in PMC: 2018 May 2.
Published in final edited form as: Cell Rep. 2017 May 2;19(5):1008–1021. doi: 10.1016/j.celrep.2017.04.019

Fig. 2. Deletion of aceA reduces fungal survival and virulence in immunocompromised mice.

Fig. 2

(A) Colony forming units (CFU) of fungal strains after incubation with murine alveolar macrophages for 2h. Experiments were carried out in triplicates; error bars represent standard deviations and statistical significance is indicated by p values.

(B) Survival rates of mice immunocompromised with cortisone acetate and infected with the A. fumigatus wild type, ΔaceA and the reconstituted strain aceAC, respectively. Statistical significance is indicated by p values. 10 mice were in each group.

(C) Survival rates of mice immunocompromised with cortisone acetate and infected with the A. fumigatus wild type, ΔmacA and ΔcufA strains, respectively. 10 mice were in each group.

(D) Survival rates of mice immunocompromised with cyclophosphamide and infected with the A. fumigatus wild type, ΔaceA and the reconstituted strain aceAC, respectively. Statistical significance is indicated by p values.

(E) Survival rates of mice immunocompromised with cyclophosphamide and infected with the A. fumigatus wild type, ΔmacA and ΔcufA strains, respectively.