Table 2. Disease characteristics, demographics, clinical characteristics, therapy, and outcomes of 7 solid organ transplant recipients with VL, Madrid, Spain, January 1, 2005–January 1, 2013*.
Characteristics | Patient no. |
||||||
---|---|---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | 6 | 7 | |
Sex | M | M | M | M | M | F | M |
Race | Black | Black | White | White | White | White | White |
Linear distance from patient’s residence to park, m | 794 | 399 | 261 | 1,240 | 985 | 233 | 358 |
Age at transplant, y | 35 | 34 | 76 | 55 | 68 | 49 | 52 |
Type of SOT | Kidney | Kidney | Kidney | Kidney | Kidney | Heart | Kidney |
Donor Leishmania spp. serostatus | Negative | NP | Negative | NP | Negative | Negative | Negative |
Pretransplant recipient Leishmania spp. serostatus | NP | NP | Negative | Positive | Negative | Negative | Negative |
Date of transplant | 2011 Feb 11 | 2010 Jan 22 | 2010 Mar 10 | 2010 Jul 7 | 2009 Dec 29 | 2010 Sep 5 | 2010 Apr 15 |
Interval from transplant to VL diagnosis, y | 1.17 | 2.44 | 0.25 | 1.4 | 0.17 | 1.81 | 2.21 |
Fever at admission | Yes | Yes | No | Yes | Yes | Yes | Yes |
Pancytopenia | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Splenomegaly | Yes | Yes | Yes | Yes | Yes | Yes | Yes |
Serologic testing results for Leishmania spp. | Positive | Negative | Negative | Positive | Negative | Positive | Negative |
Presence of amastigote forms in bone marrow sample | Positive | Positive | Positive | Positive | Positive | Positive | Positive |
PCR assay results of bone marrow sample | NP | NP | NP | Negative | NP | NP | NP |
NNN culture results of bone marrow sample | Positive | NP | Positive | Negative | Negative | Positive | Negative |
Initial therapy | L-AmB | L-AmB | L-AmB | L-AmB | L-AmB | L-AmB | L-AmB |
Relapse | Yes | No | Yes | Yes | No | No | No |
Outcome | Renal failure | Graft loss | Cured | Graft loss | Cured | Cured | Cured |
*L-AmB, liposomal amphotericin B; NNN, Novy-McNeal-Nicolle; NP, not performed; SOT, solid organ transplant; VL, visceral leishmaniasis.