Table 3.

Genes with either stop codon gains or losses in either ILS or ISS strains

	Genes with stop codon gains	Genes with stop codon lost	Function
ILS strain-specific
	Ces1b		Carboxylesterase activity
	Nck2		Recruit and bind proteins involved in regulation of receptor protein kinases, and through these regulatory activities, this protein may be involved in cytoskeletal reorganization
	Heatr7b1		Molecular binding
	Olfr411		G-protein-coupled receptor activity and olfactory receptor activity
	Mep1a		Hydrolase activity and metal ion binding
	AMY2B		Hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen
	Zbtb5		Zinc finger and BTB domain-containing protein 5
	Aurkc		ATP binding, kinase activity, possible role in oocytes and microtubules organization with the cetrozome during mitosis, and is over expressed in cancer cell lines
	Mrgprx2		G-protein-coupled receptor activity and neuropeptide binding
	Oca2		Arsenite trasnsmembrane activity
	Defb46		Antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization
	Vmn2r100		G-protein-coupled receptor
	Tmem100		Developmental protein
		lfi205	Interferon activated gene 205
		Znhit3	Thyroid receptor-interacting protein
		Scnm1	Plays a role in RNA splicing, may contribute to the recognition of nonconsensus donor sites
		Vmn2r114	G-protein-coupled receptor
ISS strain-specific
	Krt42		Structural molecule activity
	Tubb4b		GTPase activity and binding
	Sipa 1l2		Gap activity for Ras-related regulatory protiens Rap1 and Rap2
	Prex1		Guanine-nucleotide-releasing factor
	Hbq1b		Heme binding, oxygen binding
	Morn4		Unknown
		Mnda	Participates in blood cell-specific responses to interferons

Gene symbols are listed for those genes that show either a stop codon gain or loss in either the ILS or ISS strains. Functions were obtained from GeneCards’ Weizmann Institute of Science, UniProt, and MGI Mouse Genome Informatic, Jackson Labs