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High fat diet-fed mice develop urinary retention and dermatitis. The majority of SAMP6 and AKR/J HFD-fed mice develop urinary retention (A) evident as inflated bladders (B, arrow, HFD mouse) concurrent with urinary voiding dysfunction. A smaller number of HFD-fed mice also developed chronic dermatitis (A). Epididymal fat pads are notably enlarged in SAMP6 HFD-fed mice (B, asterisks).
