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Role of free fatty acids in endothelial dysfunction. Free fatty acids (FFA) stimulate endothelial apoptosis, augment vascular oxidative stress, reduce NO availability, enhance endothelial and monocyte activation and increase inflammatory responses. CRP C-reactive protein, ICAM-1 intercellular adhesion molecule-1, IκBα inhibitory subunit of NFκB, IKKβ IκB kinase-β, NFκB nuclear factor-kappa B, sE-selectin soluble E-selectin, VCAM-1 vascular cell adhesion molecule-1
