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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Hematol Oncol Clin North Am. 2017 May 18;31(4):681–692. doi: 10.1016/j.hoc.2017.04.005

Figure 1. FLT3 signaling and mechanisms of resistance to FLT3 inhibitors.

Figure 1

Wild type as well as FLT3 mutated receptor signal via Jak/STAT, PI3K/Akt and Ras/MAPK to provide anti-apoptotic as well as proliferative signaling to the leukemic blasts. Mechanisms that maintain these pathways active in the presence of FLT3 inhibitors create the conditions for the development of resistance. Combining FLT3 inhibitors with inhibitors of these pathways hold the promise of preventing development of resistance. Potential targets are highlighted in red. Point mutations in the FLT3 receptor are detailed in the rectangular insert.