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. Author manuscript; available in PMC: 2017 Nov 4.
Published in final edited form as: Org Lett. 2016 Oct 18;18(21):5449–5451. doi: 10.1021/acs.orglett.6b02722

Table 3.

O-allylaniline Substrate Scope

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entry product R1 R2 yield (%)b
1 4a H H 87
2c 4a H H 80
3 4b Me H 89
4 4c H Me 95
5 4d F H 88
6 4e Cl H 80
7 4f COOMe H 65
8 4g CF3 H 58
9 4h NO2 H 30
10 4i CN H 32
a

Amine substrate (0.5 mmol) treated with PdCl2(PhCN)2 (5 mol %), Cu(NO3)2•3H2O (5 mol %) in AcOH/Ac2O (6:1, 10.5 mL) under an O2 atmosphere (1 atm) at 23 °C for 16 h.

b

Yield of isolated product.

c

Under 1 atm air instead of oxygen.