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. 2017 Jul 14;16:119. doi: 10.1186/s12943-017-0689-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Hif-2α enhanced the activity of β-catenin. a Wnt-3a induced β-catenin promoted EMT while siRNA inhibited β-catenin blocked EMT in PANC-1 cells. b DFO promoted EMT, which was partially reversed by β-catenin interference by siRNA. c Hif-2α (A530T) promoted EMT, which was partially reversed by β-catenin interference by siRNA. d Hif-2α (A530T) transfection enhanced transcription activity of β-catenin in PANC-1 and SW 1990 cells regardless of oxygen availability. Knockdown of hif-2α reduced β-catenin activity as measured by luciferase reporter assays. *, P < 0.05; **, P < 0.01; ***, P < 0.001, as compared to pcDNA3, NaCl, or nc-siRNA. Representatives of three independent experiments