Table 5.
Sensitivity analyses
| Parameter varied in rapid arm | Per patient enrolled | Per patient achieving primary outcome | Production cost* | ||
|---|---|---|---|---|---|
|
| |||||
| Cost | Difference from standard arm (%) | Cost | Difference from standard arm (%) | ||
| Baseline scenario - actual volume and staffing | |||||
| Standard arm, for comparison | 319.08 | 0.00 (0%) | 487.45 | 0.00 (0%) | 738.16 |
| Rapid arm | 451.19 | 132.12 (41%) | 505.42 | 17.97 (4%) | 707.09 |
|
| |||||
| Patient volume set equal to full patient load of clinic (high volume)** | |||||
| Standard arm, for comparison | 319.08 | 0.00 (0%) | 487.45 | 0.00 (0%) | 738.16 |
| Rapid arm | 389.42 | 70.34 (22%) | 451.99 | −35.46 (−7%) | 610.28 |
|
| |||||
| Some tasks shifted from primary health nurse to enrolled nurse** | |||||
| Standard arm, for comparison | 319.08 | 0.00 (0%) | 487.45 | 0.00 (0%) | 738.16 |
| Rapid arm | 436.42 | 117.34 (37%) | 490.64 | 3.19 (1%) | 683.94 |
|
| |||||
| Assume missing viral loads were suppressed | |||||
| Standard arm, for comparison | 319.08 | 0.00 (0%) | 466.74 | 0.00 (0%) | 638.15 |
| Rapid arm | 451.19 | 132.12 (41%) | 490.83 | 24.09 (5%) | 615.26 |
|
| |||||
| Assume TB suspects excluded; no POC TB tests** | |||||
| Standard arm, for comparison | 309.41 | 0.00 (0%) | 481.14 | 0.00 (0%) | 760.99 |
| Rapid arm | 423.38 | 113.97 (37%) | 482.29 | 1.15 (0%) | 635.07 |
|
| |||||
| Minimum cost scenario: excluded TB suspects + high patient volume + enrolled nurse | |||||
| Standard arm, for comparison | 309.41 | 0.00 (0%) | 481.14 | 0.00 (0%) | 760.99 |
| Rapid arm | 370.09 | 60.68 (20%) | 429.64 | −51.51 (−11%) | 555.14 |
*
Production cost=total cost for all patients in arm/number of patients in arm achieving primary outcome
**
Included in minimum cost scenario